Date:december 13, 2013

37. Identification of three novel Toxoplasma gondii rhoptry proteins.

Camejo A, Gold DA, Lu D*, McFetridge K, Julien L, Yang N*, Jensen KD, Saeij JP. International Journal for Parasitology. S0020-7519(13)00222-1; 2013. [Epub ahead of print]. PDF.

By identifying Toxoplasma genes with similar cyclical expression profiles as known rhoptry protein encoding genes we identified putative novel rhoptry encoding genes. Using this approach we identified two new rhoptry bulb (ROP47 and ROP48) and one new rhoptry neck protein (RON12). ROP47 is secreted into the host cell and traffics to the host cell nucleus. However, its function is currently unclear as ROP47 knockout parasites did not have a significant phenotype in mice.